Margherita d'Este (1410-1475), m. Galeotto Roberto Malatesta
Ugo d'Este (1405-1425 ) He committed adultery with his father's second wife and was beheaded.
Leonello d'Este, duc de Modène (1407-1450) He was legitimated by the Pope in 1429. He succeeded his father in 1441 as Signore di Ferrara, Modena e Reggio.
Borso d'Este, duc de Modène (1413-1471) He succeeded his brother 1450 as Signore di Ferrara, Modena e Reggio. He was created Duke of Modena and Reggio by the Emperor 1452. He was created Duke of Ferrara by the Pope 14 Apr 1471
Niccolò III and mistress Caterina de´Medici's child:
MELIADUSE d'Este (1406-1452). Abbot of Pomposa and Ferrara, resigned 1425.
Niccolò III and mistress FILIPPA della Tavola's children:
GURONE Maria d'Este (-1484). Canon at Ferrara. Apostolic protonotary. Abbot of Nonantola Santa Maria di Gavello e Campagnola.
ALBERTO d'Este (1415-8 Apr 1502). Signore di Polesine di Rovigo 1471/74.
Niccolò III and CATARINA's children:
ISOTTA d'Este (1425-1456), m. firstly (1443) ODDANTONIO di Montefeltro, Duke of Urbino (after 1424-1444); m. secondly (1446) STEFANO Frangipani, Conte di Segni (-1481)
CAMILLA d'Este, m (1448) RODOLFO Varano di Camerino (-1464)
BEATRICE d'Este (1427-before 29 Nov 1497). m. 1st (1448) NICCOLÒ da Correggio, Conte di Corregio (-1453/54), m. 2nd (28 Oct 1454) TRISTANO Sforza, Signore di Saliceto, Noceto e Lusurasco (Genoa 1424-Milan 1477).
Niccolò III and an unknown mistress's children:
RINALDO d'Este (1435-8 Apr 1503), m. (11 Jun 1472) LUCREZIA (-after 1481).
BIANCA MARIA d'Este (18 Dec 1440-Mirandola 12 Jan 1506, bur Mirandola San Francesco), m. (1468) GALEOTTO [I] Pico, Signore della Mirandola (-7 Apr 1499, bur Mirandola San Francesco).
Wikipedia: House of Este ([ˈɛste] Italian: Casata d'Este, originally House of Welf-Este) is a European princely dynasty. It's one of the most ancient noble dynasties in Europe. The elder branch of the House of Este included the Dukes of Brunswick and Lüneburg (1208–1918) and produced Britain's Hanoverian monarchs and one Emperor of Russia (Ivan VI).
Commentary from The Estes Family in the Italian Renaissance:
"According to the Wikipedia article on the House of Este http://en.wikipedia.org/wiki/House_of_Este, The lordship of Ferrara was made hereditary by Obizzo II (d. 1293) who was proclaimed Lord of Ferrara in 1264, Lord of Modena 1288 and Lord of Reggio 1289.
Ferrara being a papal fief, the Este Family were given the position of hereditary Papal Vicars in 1332. Ferrara became a significant center of culture under Niccolò d'Este III (1384–1441), who received several popes with great magnificence, especially Eugene IV, who held a Council here in 1438 later known as the Council of Florence.
His successors were Leonello (1407–1450) and Borso (1413–1471), who was elevated to Duke of Modena and Reggio by Emperor Frederick III in 1452 and in return received these duchies as imperial fiefs.
In 1471 he received the Duchy of Ferrara as papal fief from Pope Paul II, for which occasion splendid frescoes were executed at Palazzo Schifanoia.
Both Leonello and his brother Borso were illegitimate sons (the mother of both was Stella de' Tolome. Leonello, as the eldest, became Marquess of Ferrara on his father's death. On the death of Leonello, for reasons unknown his brother Borso, instead of his son Francesco, became Marquess. And Francesco fled to northern Europe, eventually settling in England. Considering the culture of violence in that time and place, he probably fled for his life."