William was born "probably about 1550;" he was the son of Robert and Sybil Gold Fiske. According to Candler, he first married Anne Anstye (Austye, Anstyle), daughter of Walter Ansty of Tibnam Long Row in Norfolk. They had six children together who were born in South Elmham before she died; she was buried on 13 Feb 1600/1 at St. James in South Elmham, Suffolk.
William's father died about 1600 and an old record reads, "William fyske has liery of the manor and advowson of Hekingham, in county Norfolk, lately belonging to Robert Fyske, his father."
In 1601 he was a churchwarden in St. James Parish.
William Fiske married secondly to Alice (birth surname unknown) who is mentioned in his will made 25 Nov 1616 in Ditchingham, Norfolk. His will was proved on 17 May 1620 and mentions:
One widely quoted source for Fiske family genealogists is Matthias Candler, born in 1604 and educated at Cambridge. He authored the "Candler Manuscript" now housed at the British Museum. His account of the family has not been independently verified.
Candler indicates that William fled the country with his parents who were Protestants during the time of the religious persecution (1553-1558). Under the reign of Queen Mary they fled to Geneva, Switzerland. Upon the ascension of Queen Elizabeth, they returned to England. 
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