Birth: about 1628/1629 at Scituate, Plymouth, Massachusetts,  His year of birth is given as 1624 by other sources.In May, 1627 there was an event in Plymouth Colony know as the "Division of Cattle". It served as a census of the colony. Samuel was born after this event.
Samuel Fuller, son of Samuel was born a bout 1629.
Samuel, son of Samuel Fuller, Sr, and his wife Bridget Lee, was born about 1629. 
Rev. Samuel fuller was born in 1625 in Plymouth, Massachusetts. He was the son of Samuel Fuller, born before 20 January 1580 and died between 9 August 1633 and 26 September 1633 in Plymouth, Massachusetts; his mother was Bridget Lee, who died after 1633. His parents were married 27 May 1617 in Leiden, Netherlands.
1654 Liaison with Ruth Bassett
At the General Court at Plymouth on 6 Jun 1655, John2 Sprague, son of Francis, and Ruth Bassett, daughter of William, of Duxbury were "present[ed] for fornication before they were married..." indicating that the infant John was born less than 9 months after the wedding. 
Ruth Bassett was born about 1633 in Bridgewater, Plymouth, Massachusetts and died between 22 March 1692/93 and 1 January 1699/00. 
This alone would be genealogically unremarkable, but comparison of the Y-DNA of descendants of eldest son John3 to younger sons Samuel and William and other Sprague children show John3 was not John2 Sprague's biological child. These descendants match the Y-DNA haplogroup of the Fullers of Plymouth. Only Samuel2 Fuller (Samuel1), born 1625, Plymouth Colony, died 17 August 1695, Middleboro, Plymouth County, was living near Duxbury. 
Documents will likely never answer whether John2 Sprague knew that he was not the biological father of his wife's first child.
First Marriage, Name Unknown
Rev. Samuel Fuller married twice. The name of his first wife was unknown. She was the mother of his first child Samuel and possibly of his second child Elizabeth.
Samuel Fuller married second, between April 11, 1663 and May 2, 1667, Elizabeth (Nicholas) Bowen. They had seven children. 
His title was "Reverend"  He was the first minister of the First church in Middleboro, Massachusetts.
Death: Age at Death: 71 This would make him born before the cattle division. He is not listed there.
Date: 17 AUG 1695 (gravestone) or 24 Aug 1695 (Church record). The Church record reads "Mr. Samuel Fuller, the Teacher of the chh at Midlebury a sincere Godly man whom wee had the last yeare dismissed to that service, dyed August 24 being about 66 yeares old a great losse to that place."
Burial Place: Nemasket Hill Cemetery, Middleboro, Plymouth County, Massachusetts, The stone is not his original stone. From the Church's records, the inscription on his original stone reads:
"Here lyes buried ye body of ye Rev. Samuel Fuller,
who departed this life Aug. ye 17th, 1694, in ye 71st year
of his age. He was ye 1st minister of ye Church of
Christ of Middleborough."
Rev. Samuel Fuller died 17 August 1695 in Middleboro, Plymouth, Massachuetts. 
Biological Child of Samuel Fuller and Ruth Bassett
Lt. John Sprague, b. Abt 1656, Duxbury, Plymouth Co., MA, d. 6 Mar 1727/28, Lebanon, New London Co., CT (Age ~ 72 years) 
Children of Samuel Fuller and his wives
Samuel b. c. 1658, Plymouth, d. 6 Sept 1728, 70th year in Plympton; m. 7 Jan 1685/6 Plymouth, Mercy Eaton. (See MBD 1:461 and MD 3:14 for 11 children. Samuel Fuller, b. 1659, d. 6 Sep 1728, Plympton, Plymouth Co., MA (Age 69 years) 
Elizabeth Fuller b. 1663-1666, Plymouth; d. before June 1724; m. 24 May 1694, Middleboro Samuel Eaton  Elizabeth Fuller, b. 1666, Middleboro, Plymouth Co., MA,, d. Yes, date unknown 
John Fuller b. c. 1667 Plymouth; d. c. 1710 ae 42; m. c 1688 Mercy Nelson. John Fuller, b. 1663, Middleboro, Plymouth Co., MA,, d. Abt 1710, Middleboro, Plymouth Co., MA, USA (Age 47 years) 
Experience Fuller, b. c 1669 Plymout; d. between 16April 1725 (deed) and 21 Dec 1728 (husbands estate admin) m. James Wood  Experience Fuller, b. Abt 1661, Middleboro, Plymouth Co., MA,, d. Yes, date unknown 
Hannah Fuller b. c. 1671 Plymouth d. between 11 june 1707 (deed) and 1709 (husband's 2nd marriage); m. Eleazer Lewis after 27 July 1696  Hannah Fuller, b. 1668, Middleboro, Plymouth Co., MA,, d. Yes, date unknown 
Mercy Fuller b. c. 1672/3 Plymouth; d. 25 Sept 1735 buried in Eastham; m. Daniel Cole  Mercy Fuller, b. Abt 1656, Middleboro, Plymouth Co., MA d. Yes, date unknown 
Isaac Fuller b. c. 1674/5 Plymouth; d. pr 16 Nov 1727 Middleboro (adm.); m. Mary Pratt, perhaps widow of Joshua;  Isaac Fuller, b. Abt 1675, Middleboro, Plymouth Co., MA, , d. 1727, Brockton, Plymouth Co., MA, USA (Age ~ 52 years) 
Research Notes: Was his wife Elizabeth Brewster?
Some genealogies present his wife Elizabeth as Elizabeth Brewster, daughter of William. There is no evidence that William Brewster actually had a daughter Elizabeth.
About 1665 he married Elizabeth Brewster, born about 1637 and died 11 November 1713 
↑ 8.008.018.028.038.048.058.068.078.088.098.108.11 Richard E (Dick) Weber, Developer, Sprague Database of the Sprague Project. A Genealogical Database of Over 465,000 Individuals; Celebrating our twenty-third year on the internet. Sprague Mill, Upwey, England. Profile for Samuel Fuller Sourced with (1) William Hyslop Fuller, 'Samuel Fuller Genealogy. (1910) Palmer, Mass; and (2) Robert Charles Anderson, Great Migration Begins. New England Historic Genealogical Society, Boston, 1995, Volume 1, page 716. Last modified 16 January 2020. Accessed 31 August 2020 jhd
↑ 9.09.1Lt. John Sprague (ca. 1655–1727/8) of Duxbury, Mass., and Lebanon, Conn., an illegitimate son of Samuel2 Fuller (Samuel1)? by Christopher Challender Child (an NEHGS staff member), published in Volume 67, Number 2, page 177 of the Mayflower Descendant: An Illustrated Quarterly Magazine of Pilgrim Genealogy, History and Biography (Massachusetts Society of Mayflower Descendants, Summer 2019), which is not yet available in the NHEGS database but is currently referenced on the NEHGS website.
Page 26-7: "But his ministry, after his ordination, was very brief, lasting for only seven months and twenty-one days. He died in the seventy-first year of his age,and was interred in the first burying-place, commonly called the Hill."
Wakefield, Robert S., Radash, Katherine Warner, and Radash, Arthur Hitchcock, Mayflower Families through Five Generations, Volume 10, General Society of Mayflower Descendants, Plymouth, MA., Reprinted Edition, 2013 (also the 1996 printing).
It may be possible to confirm family relationships with Samuel by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
Y-chromosome DNA test-takers in his direct paternal line on WikiTree: