One family tree says this James had a James that married Mary Thompson Green who had another James born in 1792 that married Jane but with no death date. That one contained no sources. It is possible there is confusion in the different generations. Would need more sources to sort it out -- Darlene Cypser
Sources
handwritten family genealogy
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DNA Connections
It may be possible to confirm family relationships with James by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with James: