"United States Census, 1940," database with images, FamilySearch (https://www.familysearch.org/ark:/61903/1:1:K7C9-JFR : 8 January 2021), Anne Catherine Guffey in household of Francis A Guffey, Oak Hill, Fayette, West Virginia, United States; citing enumeration district (ED) 10-9B, sheet 24A, line 34, family 484, Sixteenth Census of the United States, 1940, NARA digital publication T627. Records of the Bureau of the Census, 1790 - 2007, RG 29. Washington, D.C.: National Archives and Records Administration, 2012, roll 4401.
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DNA Connections
It may be possible to confirm family relationships with Anna by comparing test results with other carriers of her ancestors' mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Anna: