Louisa is daughter of Frederick Highsaw and Mary Martha Dalton
Middle name:
Assume Missouri, based on her age on the 1870 census.
Some genealogies show sister Marietta as the one with middle name Missouri.
Reference:
Louisa & Marietta are both on 1860 census with parents, but only one remains by 1870 census. Assume one of them married (or died) before the 1870 census.
The age of "Missouri" on 1870 census, indicates she is Louisa (not Marietta).
Birth: about 1848 in Texas, based on the following:
1) born 1849 TX, per census in 1850, age 1, "E N Highson"
2) born 1848 TX, per census in 1860, age 12, "Louisa Highsaw"
3) born 1848 TX, per census in 1870, age 22, "Missouri Hisaw"
Death: unknown
Cannot locate after 1870 census with her father
MARRIAGE
Marriage: unknown
Louisa POSSIBLY married a Welch or a Lankford
There are WELCH children (shown as nieces) living with Louisa's sister Elizabeth in 1880. The WELCH children may (or may not) be children of Louisa, but it is a possibility.
Some genealogies show Marietta/Missouri married a LANKFORD, but I cannot find any evidence of a couple or a marriage.
CENSUS
1850 census: Fannin, Texas, family#265
Fred Highson ........... 42 ... KY ... farmer
M M Highson ........... 38 ... NC ... [wife Mary Martha]
Elizabeth Highson ... 15 ... TN ... [Anne Elizabeth]
M M Highson ............. 8 ... TN ... [Martha Margaret]
M Highson .................. 6 ... TX ... [Mary]
E N Highson ............... 1 ... TX ... [Louisa Missouri] <--------
James Hisaw ...... 12 ... TX ... [grandchild - child of Elizabeth]
Robert Hisaw ..... 10 ... TX ... [grandchild - child of either Mary or Marietta]
Alice A Hisaw ....... 2 ... TX .... [grandchild - child of either Mary, Marietta, Louisa]
1870 census notes:
Estate Value: real estate $500, personal estate $250
1880: cannot locate Louisa
POSSIBLE CHILDREN
1880 census: Precinct 2, Delta, Texas, family#9
Anna E. Hysow .... 46 ... TN,KY,SC ... widowed ... [sister of Louisa Highsaw]
James C. Hysow ... 22 .. TX,IL,TN ... son
Lottie A. Welch ...... 9 ... TX,MO,TX ... niece ... [CHILD OF WHO?] <--------
Mary E. Welch ....... 6 ... TX,MO,TX ... niece ... [CHILD OF WHO?] <--------
Notes:
Cannot identify the WELCH children.
They are possibly the children of either Louisa or Marietta.
Lottie A Welch, might be the "Alice Highsaw" on 1870 census.
Sources
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DNA Connections
It may be possible to confirm family relationships with Louisa Missouri by comparing test results with other carriers of her ancestors' mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Louisa Missouri: