Nancy was born after 1846. She was the daughter of Shelby Hobbs. She passed away about 1915.
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Sources
1850 census
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DNA Connections
It may be possible to confirm family relationships with Nancy by comparing test results with other carriers of her ancestors' mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Nancy: