Spouse is likely Elizabeth Hannah Jeffcott, b 1869.
Sources
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"England Births and Christenings, 1538-1975," database, FamilySearch (https://familysearch.org/ark:/61903/1:1:J32P-ZYJ : 10 February 2018, Elizabeth in entry for William Henry Holmes, ); citing - 2:2LWXK64, index based upon data collected by the Genealogical Society of Utah, Salt Lake City; FHL microfilm 1,040,585.
1881 England & Wales Census, Year: 1881; Country: England; County: Cambridgeshire; Location: Guyhern, Wisbech St Mary; Series: RG11; Piece: 1694; Enum. District: 5; Page: 70; Page: 7; Line: 24
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DNA Connections
It may be possible to confirm family relationships with William by comparing test results with other carriers of his ancestors' Y-chromosome or mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with William: