From Genealogical and Personal History of Western Pennsylvania:
He (James Agnew) married the daughter of Governor Howell, of New Jersey, her
brother being the father of Mrs. Jefferson Davis, wife of the president of
the Confederate States of America, while that league of states stood.
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It may be possible to confirm family relationships with Sarah by comparing test results with other carriers of her ancestors' mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share DNA with Sarah: