He is buried in the Pine Grove Cemetery in Lynn, Essex County, Massachusetts (Plot: Public Lot-6, Section-19, Grave-1516. This is from Find-a-Grave; this being his death location is just assumed.
↑ "Massachusetts, State Vital Records, 1841-1920," index and images, FamilySearch (https://familysearch.org/ark:/61903/1:1:23YG-19V : accessed 21 May 2015), John W Howe, 21 Mar 1917; citing Birth, Somerville, Middlesex, Massachusetts, United States, certificate number 432, page 877, State Archives, Boston.
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It may be possible to confirm family relationships with John by comparing test results with other carriers of his ancestors' Y-chromosome or mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with John: