John Irvine/Irwin, (The son of William Irvine/Irwin emigrate of Ireland) of Cumberland Co., Pennsylvania, he married Elizabeth Cunningham, who was thought to be of Welsh descent.
John and Elizabeth Irwin had 6 known children:
Elizabeth IRWIN & George WOOD
William(2) IRWIN & Elizabeth FORESTER
Francis (Frank) IRWIN - married but had no known heirs
John(2) IRWIN & Jemima Stockton
Margaret (Peggy) IRWIN & Benjamin McDowel/McDowell
Nancy IRWIN & Leven Bristow
Sources
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Find a Grave, database and images (accessed 21 November 2020), memorial page for John Irwin Sr. (1759–1815), Find A Grave: Memorial #108810326, citing Irwin Cemetery, Clinton County, Kentucky, USA; maintained by Craig Burton (contributor 47214425).
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Find a Grave, database and images (accessed 21 November 2020), memorial page for John Irwin (1755–1815), Find A Grave: Memorial #90470615; maintained by OkieBran (contributor 46530611), Burial Unknown.
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DNA Connections
It may be possible to confirm family relationships with John by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with John: