The Isham name means "the town or settlement on the Ise [River]" p. 6. The De Ishams took their name from the river. 
One ancestral line leads to Azor, a Saxon, and a significant landowner in the area during the pre-Conquest times(about the middle of the 11th century). Reputedly, he gave birth to a Roger de Isham, who was the first known person to use the name Isham. Others dispute the existence of this Roger. Azor's father was named Lefsi, and one son was named Suain/Swain, who also appears to have held a significant amount of land, but he might have lost some of it at the time of the Conquest.
At the time of the Domesday Book, in 1086, which was ordered created by William the Conqueror, and recorded the first Survey of English lands and their owners, a Henry de Isham held Isham. Besides the possible Roger, this Henry is the first documented holder of the name Isham. Henry De Isham was not a Saxon, and was the ancestor, if not father, of Henry Jr. Following this Henry De Isham, from the Domesday Book, Ishams dwelt in county Northamptonshire longer than any other family.
In the 11th Century, the name was also written Hysham, Hicham and Ysham. 
Created by Chaz Gormley on February 11, 2014.
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