Martha was born in 1772. She is the daughter of Thomas Jefferson and Martha Wayles. She passed away in 1836.  She was considered the First Lady during her father's time as President of the USA. Her mother had passed away, and Martha was the eldest of Thomas' daughters and lived in the White House.
27 Sep 1772
Martha "Patsy" Washington Jefferson was born in Monticello, Albemarle, Virginia, USA
23 Feb 1790
Martha "Patsy" Washington Jefferson married her third cousin, Thomas Mann Randolph in Virginia, USA
10 Oct 1836
Martha "Patsy" Washington Jefferson Randolph died in Edgehill, King George, Virginia, USA
↑ 2.02.1 Yates U.S. and International Marriage Records, 1560-1900
Burke's Presidential Families of the United States of America / [Hugh Montgomery-Massingberd, Editor]. - 2nd Ed. London: Burke's Peerage Limited, 1981. Print.
Virginia, Extracted Vital Records, 1660-1923 for Martha Randolph; Ancestry Record 61462 #12396; Name: Martha Randolph; [Martha Jefferson] ; Gender: Female; Death Age: 70; Death Date: 10 Oct; Death Place: Albemarle Co, VA; Father: Thomas Jefferson; Mother: Jefferson; Spouse: Thomas M Randolph. Image; Quote: Oct. 10  — In Albermarle Co., Va., aged upwards of 70, Mrs. Martha Randolph widow of Gov. Thomas M. Randolph, and the last surviving daughter of Thomas Jefferson; a lady distinguished for her talents and virtues.
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It may be possible to confirm family relationships with Martha by comparing test results with other carriers of her mitochondrial DNA.
Mitochondrial DNA test-takers in the direct maternal line: