On 13 September 1758, he married Laura Walpole, sister of Maria, Duchess of Gloucester and Edinburgh and eldest daughter of the the Honourable Edward Walpole and his wife, Dorothy Clement. They had four children, three daughters and one son.
Keppel died in 1777 and his wife survived him until 1813. His daughter Laura was wife of George FitzRoy, 2nd Baron Southampton.
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