Francis was born about 1798 and passed away in 1843.
Sources
Marriage Record
1820 US Census: Hart County, Kentucky
1840 US Census: Randolph County, Missouri
Missouri Wills and Probate Records, 1766-1988 (at Ancestry.com)
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DNA Connections
It may be possible to confirm family relationships with Francis by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Francis: