Son of Sir Francis Henry Lee, 4th Baronet of Quarendon and his wife Lady Elizabeth Pope, daughter of Thomas Pope, 2nd Earl of Downe.
Edward Lee was Fifth Baronet of Ditchley and of Quarendon.
At age 10 he was created Earl of Lichfield.
He was also Viscount Quarendon and Baron Spelsbury.
He followed James II to Rochester, Kent after the king's escape from Whitehall in December 1688.
Husband of Lady Charlotte Fitzroy. They married on 6 February 1677. They were twelve and thirteen years old when they wed. They had at least eleven children.
Children of Edward Henry Lee, 1st Earl of Lichfield and Lady Charlotte Fitzroy
Captain Hon. James Lee d. 1711
Hon. Charles Lee d. 1708
Vice-Admiral Hon. Fitzroy Henry Lee d. 1720
Lady Charlotte Lee b. 13 Mar 1678, d. 22 Jan 1721
Charles Lee, Viscount Quarendon b. 6 May 1680, d. Oct 1680
Edward Henry Lee, Viscount Quarendon b. 6 Jun 1681, d. 21 Oct 1713
George Henry Lee, 2nd Earl of Lichfield b. 12 Mar 1690, d. 13 Feb 1742
Lady Barbara Lee b. 3 Mar 1694
Robert Lee, 4th Earl of Lichfield b. 3 Jul 1706, d. 4 Nov 1766
Frederick Lewis Weis, The Magna Charta Sureties, 1215 (Baltimore, Maryland: Genealogical Publishing Company, 1999)
Sir Leslie Stephen and Sir Sidney Lee, editors, Dictionary of National Biography Founded in 1882 by George Smith (London: Oxford University Press, 1922); Line 17C; page 25: "19. CHARLOTTE FITZROY, b. perhaps 5 Sept. 1664, d. 17 Feb. 1718; m. 6 Feb. 1677, Edward Henry Lee, 1st Earl of Lichfield, b. 4 Feb 1663, d. 14 July 1716, son of Sir Francis Henry Lee, 4th Baronet, and Elizabeth Pope. (CP VII, 644).