George Lee, son of Mark Lee and Anne "Nancy" Keys was born in Kentucky c. 1790, and was baptized on his wedding day in order to give his bride a church wedding:
"LEE, George - native of "le Kenteuke" [Kentucky], brought here by his father & mother into this country since his childhood (deceased Mark - from Maryland [sic] & Nanci KAIS - also from Maryland) [sic-- other records say "from Virginia"]
bt. 7 Nov. 1815 as an adult aged 24 years on 15 March last.
He doesn't know his grandparents names.
Spons: Robert HUFFMAN & Susan CLARK.
Fr. Michel Bernard BARRIERE (Opel. Ch.: v.2, p.62)" 
He married Rachel Clark on November 7, 1815 in St Landry Catholic Church in Opelousas, Louisiana:
"LEE, George - 25 years old; native of Kentucky - inhabitant of this parish since childhood (major son of dec. Mark - originally from Maryland and Anne KAIS - also from Maryland and inhabitant of this parish for many years)
m. 7 Nov. 1815
Rachel CLARK - native of this parish (minor daughter of John - native of Baltimore & Sarah ROBERT - native of this parish for many years)
Wits: Robert HUFFMAN, Jean CLARK - father of the bride, John LEE, Nemehie PARISH, Denis STEVEN, William LEE - all inhabitants of this parish.
Fr. Michel Bernard BARRIERE (Opel. Ch.: v.1-A, p.273)" 
It may be possible to confirm family relationships with George by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
Y-chromosome DNA test-takers in his direct paternal line on WikiTree: