Not the daughter of John Lewis and Elizabeth Warner, since it is established that wealthy young lady was married to John Bolling. Also a different Elizabeth Lewis was married to Daniel Ashcraft.
Against the identification: Wrong place, very common name, contrary to what is known about Elizabeth Lewis of Virginia, wrong social class, absolutely no evidence of a connection. To say that the connection is likely because Benjamin Rush knew Meriwether Lewis is like saying Jimmy Stewart the actor is Martha Stewart's uncle. The famous Dr. Rush and our William are second cousins, once removed, William was born ca 1700 and probably married around 1730, while Benjamin was born in 1745. Meriwether Lewis was born in 1774. No connection, zilch, no chance.
The lady buried in Somerset Co PA was a daughter-in-law married to William Rush Jr.
Periodical: Jersey Baptist Church Cemetery Record
Source Locality: Lower Turkeyfoot Twp., 1.5 miles NE of Ursina
URL: via godrey.org
See Find A Grave.
Sources
Acknowledgements
This person was created through the import of Jenkins Family File w:sources 9.ged on 04 October 2010.
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DNA Connections
It may be possible to confirm family relationships with Elizabeth by comparing test results with other carriers of her mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Elizabeth: