Susan was born in 1845. She is the daughter of Valentine Lyon.
Sources
"United States Census, 1850," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:MHVS-57D : 4 April 2020), Susan M Lyon in household of Valentine Lyon, Greencastle, Putnam, Indiana, United States; citing family 52, NARA microfilm publication M432 (Washington, D.C.: National Archives and Records Administration, n.d.).
"Indiana Marriages, 1811-2007," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:XXFK-5M3 : 10 December 2017), J T Reid and Susan M Lyon, 01 Mar 1866; citing Sullivan, Indiana, United States, Marriage Registration, Indiana Commission on Public Records, Indianapolis; FHL microfilm 004170568.
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DNA Connections
It may be possible to confirm family relationships with Susan by comparing test results with other carriers of her ancestors' mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Susan: