Nancy was born 14 Feb 1793 at Jefferson County, Kentucky. 
Nancy was living with William and three children at Mary, Randolph, Illinois during the 1820 census.
Nancy was living with William and seven children at Barren County, Kentuck during the 1830 census.
In 1833 (cf. William’s first Barren County Deed), William and Nancy resettled their family on the “waters of Peter’s Creek” (Defeated Creek, today) on Antioch-Tracy Road. Until recently, remains of the "Nancy Payne house,” where she may have lived as a widow, were still standing on Defeated Creek Road. By 1860 and in 1870, Nancy was living with the family of her youngest son, V. N. Payne. The (improved) log house remembered today as the home of their son, Benjamin Payne, at the intersection of Defeated Creek (aka “Defeated Camp Creek” and “Payne Branch”) and Antioch-Tracy Road, may have been the original home of William and Nancy. 
Nancy was widowed and living with nine children at Barren County, Kentucky during the 1840 census.
Nancy was living with four of her children at Division 1, Barren County, Kentucky during the 1850 census.
Nancy was living with her son, daughter-in-law, and daughter at Distrrict 2, Barren County, Kentucky during the 1860 census.
Nancy was living with her son's family at Tracy, Barren, Kentucky during the 1870 census.
Nancy married William about 1815 at Mary, Randolph County, Illinois. In the 1810 census for Barren County, Kentucky, William appears to be widowed and have a young son living with him. Nancy and William had ten children:
Nancy would have been living near her brother, Samuel Mansker, at Mary, Randolph, Illinois from about 1815 to about 1829 according to the birth places of her children and the 1820 Mary, Randolph, Illinois census. If she married in Illinois, it would be at Mary, Randolph, Illinois.
A descendant of Nancy (Mansker) Payne, Anne (Payne) Whitney, has passed down this story about Nancy as a young girl when she was about 8 years old:
“One day she took the old horse to graze out in the woods in autumn, and kept wandering farther and farther into the forest. When it grew dark and she realized she was lost, Nancy made a bed of leaves near the horse and cried herself to sleep. Her folks searched and finally found her about sun-up, sleeping, with the horse patiently waiting by. She told her parents she had heard panthers screaming in the night but none came near.”
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It may be possible to confirm family relationships with Nancy by comparing test results with other carriers of her mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Nancy: