Margaret was born in 1836. She passed away in 1862.
Sources
"United States Census, 1850," database with images, FamilySearch (https://www.familysearch.org/ark:/61903/1:1:M85N-5GN : 20 December 2020), Margaret Marple in household of David Marple, Princeton, Bureau, Illinois, United States; citing family , NARA microfilm publication (Washington, D.C.: National Archives and Records Administration, n.d.).
"United States Census, 1860", database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:MXH7-84L : 18 February 2021), Margaret Mc Culloch in entry for James Mc Culloch, 1860.
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DNA Connections
It may be possible to confirm family relationships with Margaret by comparing test results with other carriers of her mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Margaret: