Nancy was born in 1771, daughter of John McClure. She married John Smith in 1797 and they had five children together. She died on 22 Feb 1859 in Beaver County, PA.
Children with Rev John Smith:
James Sydney Smith (1798-1871)
John McClure Smith (1799-1886)
Cynthia Smith Littell (1801-1853)
Eliza Jane Smith Shillito (1806-)
Violet Smith Shillito (1807-1892)
Sources
Commemorative Biographical Record of Washington County, Pennsylvania: Containing Biographical Sketches of Prominent and Representative Citizens, and of Many of the Early Settled Families, Part 1
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DNA Connections
It may be possible to confirm family relationships with Nancy by comparing test results with other carriers of her mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Nancy: