Paternal relationship is confirmed through Y-chromosome DNA testing. Richard McDonald and M.S. McDonald match on 37 out of 37 markers, thereby confirming their direct paternal lines back to their MRCA James McDonald I.
Sources
"United States Census, 1850," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:M8DQ-4PF : 12 April 2016), George Mcdonald in household of Evan Mcdonald, Hampshire county, Hampshire, Virginia, United States; citing family 1814, NARA microfilm publication M432 (Washington, D.C.: National Archives and Records Administration, n.d.).
Acknowledgements
WikiTree profile McDonald-2131 created through the import of Allen-Carpenter - 2010-01-31.ged on Apr 26, 2012 by Thomas Allen. See the Changes page for the details of edits by Thomas and others.
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DNA Connections
It may be possible to confirm family relationships with George by comparing test results with other carriers of his ancestors' Y-chromosome or mitochondrial DNA.
Y-chromosome DNA test-takers in his direct paternal line on WikiTree:
Melissa, if you want to list this as a source (in standard source citation wording) on relevant profiles, that's one thing, but the way you've promoted your book here is like an advertisement, which is not allowed on WikiTree.