"United States Census, 1850," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:M65K-MGG : accessed 19 March 2016), James Mead in household of Reuben Mead, Pike county, Pike, Kentucky, United States; citing family 858, NARA microfilm publication M432 (Washington, D.C.: National Archives and Records Administration, n.d.).
This lists a James Mead born the same year as Jane Mead. Was this a mistake? There is evidence for a Jane Mead. Need to confirm that James does not actually exist.
Sources
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DNA Connections
It may be possible to confirm family relationships with James by comparing test results with other carriers of his ancestors' Y-chromosome or mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with James: