"United States Census, 1880," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:MCFS-M8K : 11 September 2017), Catharine E Nicholls in household of Peter H Nicholls, Reddies River, Wilkes, North Carolina, United States; citing enumeration district ED 221, sheet 204B, NARA microfilm publication T9 (Washington, D.C.: National Archives and Records Administration, n.d.), FHL microfilm 1,254,987.
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DNA Connections
It may be possible to confirm family relationships with Catherine by comparing test results with other carriers of her ancestors' mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Catherine: