Removed parents because dates do not work.
On Ancestry, there are many trees that have William's father as John Pierce (1680-1765) and his mother as Ennice Briggs (1680-1705).
Sources
Source: S1365875324 FamilySearch Family Tree Publication: MyHeritage Note: The FamilySearch Family Tree is published by MyHeritage under license from FamilySearch International, the largest genealogy organization in the world. FamilySearch is a nonprofit organization sponsored by The Church of Jesus Christ of Latter-day Saints (Mormon Church). https://www.myheritage.com/research/record-40001-879432448/william-pierce-in-familysearch-family-tree Note: Event: Record Role: 40001:879432448: William PierceBirth name: William Pierce Sr Gender: MaleBirth: 1705 - Essex, Virginia, United StatesMarriage: Spouse: Elizabeth Rucker - 1725 - Virginia, United States Death: Mar 20 1760 - St. Mark's Parish, Orange, Virginia, United States Wife: <a>Elizabeth Rucker</a>Children: <a>William Pierce</a>, <a>James Pierce</a>, <a>Jeremiah Pierce</a>
Pierce-5817 was created by Ethan Worley through the import of Worley Family Tree.ged on Sep 6, 2015. User ID: 552F1C6886D415FF46C71D96F582E324
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DNA Connections
It may be possible to confirm family relationships with William by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with William: