Daniel Prentice was born about 1741 but his exact origins are unknown. He lived the majority of his life in the area of Virginia which straddles the current Virgnia/West Virginia line. He married Isabel Wesley about 1765, most likely in that same region.
Daniel and Isabel were parents to as many as seven children but all have not been confirmed. For those listed below some still need verification as only Daniel can be confirmed as a child of this couple through primary sources. Lucretia is included through a recorded marriage bond and the others through oral tradition.
However, beginning ca 1764, Daniel Prentice did leave behind a significant paper trail for his property, but only his wife Isabel is named in these records. Around 1790 Daniel sold his property and moved further south and west to the area known for a short time as the State of Franklin, now eastern Tennessee. This information was recorded in the sale deed of the 1790 transaction.
Daniel's death was not recorded but is believed to have occurred ca 1800-1810 in Tennessee. This date range and location are the most likely scenario, based on the statement in the 1790 deed, and his wife Isabel is purchasing land in her own name by 1810 in Sevier County, Tennessee.
31 Oct 1764, Augusta, Co. VA, Daniel Prentice on bond payable to Zebulon Harrison
18 Nov 1767 John Harrison's estate settlement. Cash paid...
Botetourt Co. Va., 22 May 1770 where he had a survey done on 93 acres of land on the south side of James River on Potts Creek. 
Tithable List 17 John May List of Tithables Botetourt 1771, page 39, Daniel Prentice 1
Tithable List 19 The list of Tithables on Jackson's River including the Cow pasture and Down James River as Low as James Laurences. Taken According to order Court by John Robinson, June 10th 1772. Daniel Prentice 1
1791, according to a Botetourt Co., Va. Deed (book 4, page 371), Daniel and Isabel sold their land to Samuel Dew. The sold land is described as on Potts Creek, near Carpenter's line, 170 acres, except for small parcel within the bounds, granted to members of Methodist Episcopal Church for a building and grave yard.
A possible ancestor of this Daniel Prentice is Valentine Prentice of Westmoreland County, Virginia. He arrived in 1654 and is recorded as witness to a deed in 1668.
Confusion with Daniel Prentis
There are two men living in Virginia during Colonial times named Daniel Prentis/Prentice. Thankfully the men spell the surname differently, one P R E N T I S, the other P R E N T I C E. Many researchers are keen to connect this Daniel Prentice with Daniel Prentis son of William Prentis storekeeper of Williamsburg, whose issue distinguished themselves as statesmen during Colonial, Revolutionary War, and early United States events. However, there does not seem to be any close relationship between the families. Also, Daniel Prentis lives in the coastal areas of Virginia, specifically Williamsburg City and Warwick County; whereas this Daniel Prentice lives in the mountain inland areas of Augusta and Botetourt Counties. See Daniel Prentis.
↑ 1.01.1 Kentucky, Death Records, 1852-1963, Kentucky Birth, Marriage and Death Records – Microfilm (1852-1910). Microfilm rolls #994027-994058. Kentucky Department for Libraries and Archives, Frankfort, Kentucky. Prentice, Daniel
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It may be possible to confirm family relationships with Daniel by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Daniel: