Only Daniel can be confirmed as a child of this couple through primary sources. Lucretia is included through a recorded marriage bond and the others through oral tradition.
Daniel Prentice was born about 1740 in Virginia (or Tennessee) and lived in Virginia most of his life. There are few documents recording his life, but the those which do exist give the name of his wife and several children. Around 1790 Daniel moved to the area of Virginia which became modern Kentucky. His death was not recorded but is believed to have occurred about 1805.
Confusion with Daniel Prentis
There are two men living in Virginia during Colonial times named Daniel Prentis/Prentice. Thankfully the men spell the surname differently, one P R E N T I S, the other P R E N T I C E. Many researchers are keen to connect this Daniel Prentice with Daniel Prentis son of William Prentis storekeeper of Williamsburg, whose issue distinguished themselves as statesmen during Colonial, Revolutionary War, and early United States events. However, there does not seem to be any close relationship between the families. Also, Daniel Prentis lives in the coastal areas of Virginia, specifically Williamsburg City and Warwick County; whereas this Daniel Prentice lives in the mountain inland areas of Augusta and Botetourt Counties. See Daniel Prentis.
31 Oct 1764, Augusta, Co. VA, Daniel Prentice on bond payable to Zebulon Harrison
18 Nov 1767 John Harrison's estate settlement. Cash paid...
Botetourt Co. Va., 22 May 1770 where he had a survey done on 93 acres of land on the south side of James River on Potts Creek. 
Tithable List 17 John May List of Tithables Botetourt 1771, page 39, Daniel Prentice 1
Tithable List 19 The list of Tithables on Jackson's River including the Cow pasture and Down James River as Low as James Laurences. Taken According to order Court by John Robinson, June 10th 1772. Daniel Prentice 1
1791, according to a Botetourt Co., Va. Deed (book 4, page 371), Daniel and Isabel sold their land to Samuel Dew. The sold land is described as on Potts Creek, near Carpenter's line, 170 acres, except for small parcel within the bounds, granted to members of Methodist Episcopal Church for a building and grave yard.
A possible ancestor of this Daniel Prentice is Valentine Prentice of Westmoreland County, Virginia. He arrived in 1654 and is recorded as witness to a deed in 1668.
↑ 2.02.1 Kentucky, Death Records, 1852-1963, Kentucky Birth, Marriage and Death Records – Microfilm (1852-1910). Microfilm rolls #994027-994058. Kentucky Department for Libraries and Archives, Frankfort, Kentucky. Prentice, Daniel
↑ Chalkley, Lyman 1966 (1912) Chronicles of the Scotch-Irish Settlement in Virginia, Vol. 1. Baltimore, MD: Genealogical Pub. Co., Judgments August 1770
↑ Chalkley, Lyman 1966 (1912) Chronicles of the Scotch-Irish Settlement in Virginia, Vol. 3. Baltimore, MD: Genealogical Pub. Co., Prentice, Danl. Pg 59
↑ Summers, Lewis Preston,. Annals of southwest Virginia, 1769-1800. Abingdon, Va.: L.P. Summers, 1929.
↑ 6.06.1 Genealogy of some of the descendants of Thomas Dew : colonial Virginia pioneer immigrant, together with genealogical records an
Author; Ancestry.com, 2005, Provo, UT
↑ 7.07.17.27.126.96.36.199 Treacy, K. W. (2014). Botetourt County, Virginia lists of tithables, 1770-1782. Athens, GA: New Papyrus Company. Index - Prentice, Daniel, 17, 19, 43, 61, 71, 84, 99, 117
↑ Burton, Charles T.. Botetourt County, Va., 1785 enumeration. Troutville, Va.: Burton?, 1972.
↑ Chilton, Ann, Botetourt Co., VA, Will Book A, 1770-1801, pg 284
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It may be possible to confirm family relationships with Daniel by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share DNA with Daniel: