"United States Census, 1850," database with images, FamilySearch (https://www.familysearch.org/ark:/61903/1:1:M8DV-HXK : 23 December 2020), John W Propst in household of William Propst, Pendleton, Virginia, United States; citing family , NARA microfilm publication (Washington, D.C.: National Archives and Records Administration, n.d.).
"West Virginia Deaths, 1804-1999," database, FamilySearch (https://familysearch.org/ark:/61903/1:1:F1TW-M1M : 10 March 2018), William Propst in entry for John Wesley Propst, 19 May 1922; citing Pendleton, West Virginia, County Records, 6682, county courthouses, West Virginia; FHL microfilm 1,953,048.
"West Virginia Marriages, 1780-1970," database, FamilySearch (https://familysearch.org/ark:/61903/1:1:FR68-DSC : 11 February 2018), Wm. Propst in entry for John W. Propst and Susannah Mitchell, 31 Mar 1872; citing Pendleton, West Virginia, p 20, county clerks, West Virginia; FHL microfilm 818,558.
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It may be possible to confirm family relationships with John by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with John: