From “Pioneer Girl: Fact and Fiction of Laura Ingalls Wilder”:
Caroline Lake Quiner was born 12 December 1839, in Brookfield (Milwaukee County) Wisconsin, the fifth of eight children of Henry Newton Quiner and Charlotte Wallis Tucker. She had older brothers Joseph (born 1834) and Henry (born 1835), and older sister Martha Jane (born 1837). Younger siblings included sister Eliza (born 1842) and brother Thomas (born 1844). A sister, Martha Morse, lived from 1832-1836.
In October 1844, Caroline's father died, and her mother moved the family to Concord, in Jefferson County. Charlotte Quiner married Frederick M. Holbrook on 2 June 1849. They had one daughter, Charlotte, in 1854; she was Laura Ingalls's "Aunt Lotty" from in Little House in the Big Woods (see Chapter 10, "Summertime"). Although the Holbrooks had moved to Rome, Wisconsin in 1854, Lotty Holbrook did spend time in Pepin County visiting her half-siblings.
Caroline became a school teacher. Her contract for three months school in Concord, dated October 1858, indicated that she was paid $10 per month. The Holbrooks lived just southwest of the Lansford Ingalls family in Concord Township, and it was here that Caroline met Charles Ingalls. On February 1, 1860, they were married, witnesses were Peter Ingalls and Martha Quiner. There were two other Ingalls-Quiner marriages: Henry Quiner married Polly Ingalls in 1859 and Peter Ingalls married Eliza Quiner in 1861.
In September 1863, Charles Ingalls and his brother-in-law, Henry Quiner, purchased land in Pepin County. Charles and Caroline settled on the south half of the quarter section, and Henry and Polly settled on the north side. Charles and Caroline Ingalls had two daughters born in Pepin County: Mary Amelia (born January 10, 1865) and Laura Elizabeth (born February 7, 1867). Daughter Carrie was born in Rutland Township (Montgomery County) Kansas on August 3, 1870. Son Charles Frederick was born November 1, 1875, in Walnut Grove (Redwood County) Minnesota; he died August 27, 1876, in South Troy (Wabasha County) Minnesota. Daughter Grace Pearl was born May 23, 1877, in Burr Oak (Winneshiek County) Iowa.
In every place the Ingallses lived and in every situation they faced, Caroline Ingalls remained a calm and staunch supporter of her husband and family.
Caroline Ingalls died in De Smet, South Dakota, on April 20, 1924 (Easter Sunday), and was buried in the De Smet cemetery. Her obituary in the De Smet News & Leader read:
Kingsbury County lost one of its pioneer women in the death of Mrs. C.P. Ingalls at her home here Sunday. She and her husband came to this locality in 1879 and lived in a claim shanty on the north shore of Silver Lake before there was a De Smet.
The death was unexpected and followed an illness of but a short time, altho Mrs. Ingalls had been feeble all winter.
Caroline Quiner was born Dec. 12, 1839, at Milwaukee, Wis., and died at 5 o'clock p.m. Easter Sunday, April 20, 1924, at the age of 84.
She was married to Charles Ingalls of Milwaukee Feb. 1, 1860, whose death occurred June 8, 1902.
Five children were born to this union, Mary Ingalls of De Smet; Laura Wilder of Mansfield, Mo.; Caroline Swanzey of Keystone, S.D.; Frederick Ingalls, who died in infancy, and Grace Dow of De Smet.
The family moved to De Smet in 1879 where they have since resided. In 1880 Mr. and Mrs. Ingalls helped organize the Congregational Church at De Smet and were faithful members of the organization to the end of their lives. Mrs. Ingalls was also an early member of the Eastern Star chapter at De Smet.
Besides the four daughters the deceased is survived by three sisters, and one granddaughter, Rose Wilder Lane.
Mrs. Ingalls was a good mother, a good neighbor, and a good friend. The last few years she has been unable to get around to see people very much or to attend church, but her interest has been with her neighbors, friends and church. It was a pleasure to go and visit her as she was always interested, bright and happy.
Find A Grave, database and images (https://www.findagrave.com : accessed 14 May 2019), memorial page for Caroline Lake Quiner Ingalls (12 Dec 1839–20 Apr 1924), Find A Grave: Memorial #3951, citing De Smet Cemetery, De Smet, Kingsbury County, South Dakota, USA ; Maintained by Find A Grave.
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It may be possible to confirm family relationships with Caroline by comparing test results with other carriers of her mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Caroline: