Reuben was the son of David and Rebecca (Sutphen) Randolph of Lebanon, Warren County, Ohio. He was born in 1807. He married Elizabeth Beauchamp on February 11, 1829, in Lebanon. They moved to Carroll County, Indiana, in the early 1830's, where Reuben was a farmer. Their children were Moses, William, Martha, John, James, David, Benjamin, Rebecca, and Elizabeth. Reuben died of liver failure in May of 1850 and is buried in Carroll County, Indiana.