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It may be possible to confirm family relationships with Thomas by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
Y-chromosome DNA test-takers in his direct paternal line on WikiTree:
Both my cousin Pete Colbert and I have GED matches with Richard Randolph M144224. Thomas Jefferson Randolph married Elizabeth (Nancy) Colbert. The Colbert's were former slaves of Thomas Jefferson and his daughter Martha Jefferson Randolph. Richard A. Colbert C-238, firstname.lastname@example.org