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www.familytreedna.com, Reynolds DNA-Genealogy Project -Y-DNA Classic Chart in Group 36, has three positive YDNA matches for James Reynolds 1761-1818 one is from Anderson Reynolds family ancestors (kit #94288) and one is from Tandy Reynolds family ancestors (kit #836143) and one from Humphrey Reynolds family ancestors (kit #886217)
It may be possible to confirm family relationships with James by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
Y-chromosome DNA test-takers in his direct paternal line on WikiTree: