William Richardson was born about 1640, possibly in Accomack County, Virginia. He may be the William Richardson who was recorded as living in the Maryland Colony by 1671 after being transported by his father, Robert Richardson.In 1666 he moved to West River Hundred, Anne Arundel County, Maryland. He was married there in 1667, to Elizabeth Ewen (b. 06 June 1630?, Virginia? or England?; d. 01 January 1703/04, Anne Arundel County, Maryland), daughter of Richard Ewen and Sophia Scarborough.
Prior to 1680, William Richardson acquired "Watkins Hope" (near Owensville), part of this land now called "Woodstock", in West River Hundred, Anne Arundel County, Maryland. He was a Quaker minister and the Quaker meetings were held at his home. He was a personal friend of William Penn, who came to visit him in 1682.
William became a large landowner and was in possession of over 4000 acres of land at the time of his death, which occurred on 02 September (or 02 November) 1697, presumably at his home at "Watkins Hope", West River Hundred, Anne Arundel County, Maryland.
Marriage & Children
William was likely married to a first unknown wife who was the mother of his two eldest sons:
William Jr. b. abt. 1672 m. Margaret Smith in 1697
Daniel b. abt. 1674
William was married to Elizabeth, the widow of Richard Talbott, and the mother of Edward Talbot before 1677. A birth record found in the West River Minutes gives a birthday of 6th day of 9th month 1658 for Edward Talbott, son of Richard and Elizabeth. Some researchers place her as Elizabeth Ewen before her marriage. The first evidence of William and Elizabeth in Quaker records is the following:
"Sophia Elizabeth Richardson, dau. of William and Elizabeth, d. 2nd day of 7th month, 1678."
The births of the following children are recorded in the West River Quaker church:
Joseph b. 3rd day 2nd month 1678
Sophia & Elizabeth b. 2nd day of 5th month 1680, 2 or 3 hours with night, Sophia being first born.
The next entry in Quaker records for this family is the death of William Richardson Sr. on the 2nd day of the 9th month of 1697. 
Abstract of Will
1st day of the tenth month called December 1691, I William Richardson, Senr. being sick and weak in body . . .
I give to my two sons, Daniell & Joseph, those five patents of land, known by the names of Henry Hills & Franklin’s Enlargement, lying between South River & the branches of Patuxant River about 600 acres to be equally divided among them, Daniell to have that moiety that Hugh Abrahams, now lieveth upon and Josph to have the next plantation.
To my loving wife, Eliza Richardson, the use of my now dwelling plantation known by the name of Watkins his Hope, during her natural life, my eldest son, William, to have occasion to make use of any part of the tract or timber before his mother’s decease.
I give to my dear grandchild, Wm. Richardson 50 acres of land if he shall live to attain age 21 years laid out at the southeast end of the aforesaid land.
I give to my daughter Sophia Richardson a tract called The Deligent Search, lying in the branches of Roade River 75 acres.
I give to my daughter, Sophia Richardson, one negro girl named Mary to be delivered her when she shall attain age 16 years or the day of her marriage.
I give to my youngest son, Joseph, one negro boy called Cargoe to be delivered when he attains age 19 years.
I give to my grandson, Wm. Richardson, one negro girl known by the name of Susan, to be delivered for his use after my wife’s decease, if then living, if not then to his father or mother.
I give to my grandson, Wm. one cow calf to be delivered two years after my decease.
I give to Eliza, daughter of John Talbot & Sarah Talbot, one cow calf, to be delivered two years after my decease.
I give to the three children of Edward Talbot, each of them, one cow calf to be delivered two years after my decease.
I give to Margaret Richardson, the wife of Wm. Richardson Jr., one two year old heifer to be delivered two years after my decease.
I give to the stock of Friends, in scorne called Quakers, five pounds sterling money to be paid within three years after my decease.
The remaining part of my personal estate found in Maryland or in England be equally divided into three parts and my loving wife to take her choice of one third part and the other two thirds be equally divided into four parts and one part to my eldest son, Wm. Richardson and another to my son Daniell Richardson and another part to my son Joseph Richardson, the other part to my daughter Sophia Richardson.
I will that Joseph’s part and Sophia’s part shall remain in their mother’s hands until they attain their several ages.
I appoint my loving wife, Eliza Richardson and my son William Richardson, my executors desiring my friends Richard Johns, Richard Harrison, John Talbott and Wm. Coles overseers.
My intent is that the three negro children that I have given to my children called Cargo, Mary & Susan shall serve until they attain the ages of fifty years and then be set free.
Signed by Wm. Richardson (with a signature) in the presence of James Elpinstone, John Westnult, John Elsey. Probated 28 MAY 1698. 
It may be possible to confirm family relationships with William by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share DNA with William:
Prominent Quaker who came to Maryland in 1665 on the ship "Constant Friendship". He was a close friend of William Penn and Lord Baltimore, a large landower, and an influential member of the Maryland Legislature. At one time, a Richardson owned much of the land on which the city of Baltimore now stands, but it appears that his widow, whom he married late in life, leased it for 99 years and returned to England.
-- charts of H. N. Buck, 1965
William Richardson resided on his plantation at West River, Anne Arundel Co., Maryland, which was known as "His Lordship's Justice". He was active in the affairs of the Society of Friends and was one of their leaders.