William Rose and his family were in South Carolina until about 1804. Frederick Rose and his family resided in Greene County, Georgia; Frederick was William's uncle. This would explain why William was in Greene County, Georgia.
He married Frances "Frankey" Burch on 13 Jun 1804 in Greene County, Georgia.
The Burch family were neighbors of William Rose in South Carolina as shown in land deeds. Henry Burch (who was enumerated on the 1800 US census in Pendleton District with a daughter aged 11-15 years and 3 daughters aged 16-20 years) was mentioned in a deed of land granted by William Rose in Pendleton District, South Carolina.
He was enumerated on the 1830 and 1840 US censuses in Whitley County, Kentucky.
Later in life, it is likely that he married Nancy Green on 9 Jul 1856 in Whitley County, Kentucky, although there is also the possibility that this could've been a different William Rose; there were many men named William Rose in Whitley County.
Notes on Familysearch suggest that WIlliam was a pioneer in Whitley County, Kentucky; that he contributed to the government and pioneer farm industry; and that he had been a patriot in the Revolutionay War. More research is needed to confirm these as facts.
Sources
↑ Find a Grave, database and images (https://www.findagrave.com/memorial/119291491/william-rose: accessed 04 July 2023), memorial page for William Rose (1 Dec 1780–May 1860), Find A Grave: Memorial #119291491; Burial Details Unknown, Currently Unknown; Maintained by Sue Ann Hornung Davis (contributor 47567877).
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DNA Connections
It may be possible to confirm family relationships with William by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with William: