John was the son of Sir John Savage of Clifton, Cheshire, knight of the Bath, and knight of the Garter, who was killed in 1492 at the siege of Boulogne, France, and his wife, Dorothy Vernon, the daughter and heir of Ralfe Vernon of Shepbrooke.
John was his parents only son, but he had several sisters:
Alice, who was married to sir William Brereton of Brereton in Cheshire, Lord Justice of Ireland;
Felicia, who was married to Robert Milward, of Eaton in Derbyshire, esq;
John also had an illegitimate brother, George Savage, parson of Davenham, Cheshire, or of Dunham in Dunham.
John married Anne, the daughter of Raufe Bostock of Bostock in Davenham parish, esq, and the sister of William Bostocke, who was living in 22 Edward IV, but after William's death Anne became her father's heir, or coheir.
John and Anne had children:
John Savage, heir, born 1493, married Elizabeth, the daughter of Charles Somerset, earl of Worcester;
Knighted in about 1497, known as Sir John Savage of Hanley in Worcestershire and Sir John Savage of Clifton, knight, he was sheriff of Worcestershire for 24 years from the death of his father. He inherited the office of High Sheriff and was given the Earl of Warwick's lands in Worcestershire in recompense for his father's death during Henry VII's siege of Bollein.
Sir John's son, Sir John the younger, killed John Pauncefote, and they were both indicted for murder, this Sir John confessed and was indicted as accessory, although they were both pardoned in 1520 through the intervention of Sir John the younger's father-in-law, Charles earl of Worcester the king's chamberlain, and cardinal Wolsey.
Sir John Savage, senior, knight, died on 2 March 1527, and an Inquisition post mortem held in 19 Henry VIII found that his son and heir, John Savage, was 34 years of age and more.
Helsby, Esq, Thomas, eds. "Containing the Introduction and Prolegomena, the county of the city of Chester and Bucklow Hundred", The History of the County Palatine and City of Chester; Compiled from Original Evidences in Public Offices, the Harleian and Cottonian MSS, Parochial Registers, Private Muniments, Unpublished Ms Collections of Successive Cheshire Antiquaries, and a Personal Survey of Every Township in the County; incorporated with a republication of King's Vale royal, and Leycester's Cheshire antiquities, 2nd Edition. Compiled by George Ormerod, Esq, LLD, FRS & FSA. I. London: George Routledge and Sons, 1882.
Rylands, John Paul, eds. "The visitation of Cheshire in the year 1580 made by Robert Glover, Somerset Herald, for William Flower, Norroy king of arms, with numerous additions and continuations, including those from the visitation of Cheshire made in the year 1566, by the same herald. With an appendix, containing the Visitation of a part of Cheshire in the year 1533, made by William Fellows, Lancaster Herald, for Thomas Benolte, Clarenceux king of arms. And a fragment of the Visitation of the City of Chester in the year 1591, made by Thomas Chaloner, deputy to the Office of arms". The Publications of the Harleian Society. XVIII. London: Harleian Society, 1882. https://archive.org/stream/visitationofches00glov#page/n9/mode/2up.