Margaret was born in 1849. She was the daughter of John Schaeffer. She passed away in 1917.
Sources
"United States Census, 1850," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:MXQ9-M8Y : 12 April 2016), Reuben Shaffer in household of John Shaffer, Gorham, Fulton, Ohio, United States; citing family 1080, NARA microfilm publication M432 (Washington, D.C.: National Archives and Records Administration, n.d.).
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DNA Connections
It may be possible to confirm family relationships with Margaret by comparing test results with other carriers of her ancestors' mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Margaret: