"United States Census, 1860," database, FamilySearch (https://familysearch.org/ark:/61903/1:1:MCG6-3B8 : accessed 23 November 2015), Nelly Twining in household of Chas A Twining, Township Of Russia, Lorain, Ohio, United States; from "1860 U.S. Federal Census - Population," database, Fold3.com (http://www.fold3.com : n.d.); citing p. 20, household ID 140, NARA microfilm publication M653 (Washington, D.C.: National Archives and Records Administration, n.d.); FHL microfilm 805,002.
"United States Census, 1870," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:M6LM-FWX : 12 April 2016), Nellie Twining in household of Charles Twining, Ohio, United States; citing p. 1, family 3, NARA microfilm publication M593 (Washington D.C.: National Archives and Records Administration, n.d.); FHL microfilm 552,734.
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It may be possible to confirm family relationships with Nellie by comparing test results with other carriers of her mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Nellie: