A Charles Setchell, not Issac, married Ann Pickering in the Sep quarter 1856 in Luton registration district.
What's the source that he was Issac. I can't find him in any census with his wife after his marriage. Unless in 1861 he was living in St Pancras, London with his widowed mother Mary. He was aged 33 married born Dean Beds, a shoemaker. It would be interesting to get hold of the birth cert of one the children to see how the father is described. What was his occupation on his marriage cert?
Have you taken a DNA test? If so, login to add it. If not, see our friends at Ancestry DNA.
Isaac is 32 degrees from Sacajawea Charbonneau, 32 degrees from Sadie Canning, 33 degrees from Hohepine Cooper, 40 degrees from Mateo Cariño, 36 degrees from Angel Decora, 36 degrees from Emma Naea, 35 degrees from Vi Hilbert, 37 degrees from Doreen Wanganeen, 32 degrees from Louis Riel, 33 degrees from Maria Tall Chief and 33 degrees from Teddy Odum on our single family tree. Login to find your connection.