Anne was born 28 September 1571, when her brother William was seven years old. Unfortunately, tragedy befell the family yet again when Anne died at the age of eight. The cause is uncertain but it is probable that Anne died of the Black Death, or the Plague. The sorrow felt by the Shakespeares' over the loss of Anne was profound, and even though they were burdened by numerous debts at the time of her death, they arranged an unusually elaborate funeral for their cherished daughter. Anne Shakespeare was buried on April 4, 1579.
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