Sarah first married John Major and apparently had no children by him. They apparently divorced by 1880 when Sarah is listed as such in her sister Minerva Burkhart's household.
Sources
1850 Knox/TN census for John S Major: no children
1860 Dist.6/Union/TN: no children
Shell cemetery, Harbison Crossroads, Knox, TN
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DNA Connections
It may be possible to confirm family relationships with Sarah by comparing test results with other carriers of her ancestors' mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Sarah: