"United States Census, 1880," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:MFNY-8X6 : 15 July 2017), James E Simpson in household of W D Simpson, Precinct 1, Leon, Texas, United States; citing enumeration district ED 86, sheet 109A, NARA microfilm publication T9 (Washington, D.C.: National Archives and Records Administration, n.d.), FHL microfilm 1,255,316.
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It may be possible to confirm family relationships with James by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share DNA with James: