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He lived in Cave City, Kentucky. His will is dated 8 JUL 1822 in Barren County, Kentucky and was probated in 1827 (Will Book 2, Page 404) Copy of will on FamilySearch
This link to Issac mentions several other references to Issac Smith.
Thank you to Kitty Smith for contributions to this profile. "United States Census, 1820," database with images, FamilySearch (https://familysearch.org/ark:/61903/3:1:33S7-9YY1-S7V3?cc=1803955&wc=3L7F-ZPF%3A1586986501%2C1586986932%2C1586984616 : 16 July 2015), Kentucky > Barren > Not Stated > image 34 of 39; citing NARA microfilm publication M33, (Washington D.C.: National Archives and Records Administration, n.d.).
Marriage Bond for Issac Smith and Patty Weatherford, 03 Jan 1809.
Family Search Tree - Unverified.
http://www.genealogy.com/forum/surnames/topics/smith/59336/
Find A Grave: Memorial #214523091
http://wc.rootsweb.ancestry.com/cgi-bin/igm.cgi?op=GET&db=:2482105&id=I0914
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