George was living with his parents in 1850.
1850 Census: Jesse Smith age 56 b Tennessee, Mary Smith age 57 b TN; John Smith age 19 b TN; George Smith age 31 b TN; Isaac Smith age 17 b IL; Mary J. Gephart age 15 b IL: Mary I. Smith age 5 b IL res. Vermilion Co., IL. 
Married Elizabeth Hester 1831-1888
1860 Census, Elwood Township, Vermilion, Illinois.
↑ "United States Census, 1850," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:M85Q-6BN : 12 April 2016), Jesse Smith, Vermilion county, part of, Vermilion, Illinois, United States; citing family , NARA microfilm publication M432 (Washington, D.C.: National Archives and Records Administration, n.d.).
↑ "United States Census, 1880," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:MXKP-8YG : 17 August 2017), George W Smith, 1880; citing enumeration district ED 213, sheet 418D, NARA microfilm publication T9 (Washington D.C.: National Archives and Records Administration, n.d), roll 0255; FHL microfilm 1,254,255.
It may be possible to confirm family relationships with George by comparing test results with other carriers of his ancestors' Y-chromosome or mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share DNA with George: