"United States Census, 1850," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:M44J-KC3 : accessed 27 May 2016), James Smith in household of Elisha Smith, Southampton, Bedford, Pennsylvania, United States; citing family 34, NARA microfilm publication M432 (Washington, D.C.: National Archives and Records Administration, n.d.).
"United States Census, 1910," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:MG39-5QQ : 29 October 2015), James S Smith in household of Aquilla Smith, Mann, Bedford, Pennsylvania, United States; citing enumeration district (ED) ED 22, sheet 8A, NARA microfilm publication T624 (Washington, D.C.: National Archives and Records Administration, n.d.); FHL microfilm 1,375,325.
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It may be possible to confirm family relationships with James by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage (beta) of DNA with James: