Eli Spencer lived in Appalachia, in North Carolina. See Appalachia Project.
Eli was born in 1817. Eli Spencer passed away in 1879.
Sources
"North Carolina Marriages, 1759-1979," database, FamilySearch (https://familysearch.org/ark:/61903/1:1:F8YJ-BP2 : 10 February 2018), Eli Spencer and Lucinda Mowser, 19 Aug 1841; citing Lincoln,North Carolina, reference ; FHL microfilm 6,330,321.
"Find A Grave Index," database, FamilySearch (https://familysearch.org/ark:/61903/1:1:QVV6-YYP3 : 26 July 2019), Eli Spencer, 1879; Burial, Conover, Catawba, North Carolina, United States of America, Fairgrove United Methodist Church Cemetery; citing record ID 11350576, Find a Grave, http://www.findagrave.com.
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DNA Connections
It may be possible to confirm family relationships with Eli by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Eli: