Melissa was born in 1838. She was the daughter of Julia Cadwallender. She passed away about 1900.
Sources
West Virginia, Marriage Records, 1856
West Virginia, Marriage Records, 1900
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DNA Connections
It may be possible to confirm family relationships with Melissa by comparing test results with other carriers of her ancestors' mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Melissa: