Margaret was born in 1794. Margaret Vickery ... She passed away in 1875. 
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↑ First-hand information as remembered by Victor J, Monday, October 6, 2014. Replace this citation if there is another source.
"United States Census, 1850," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:M65P-2RH : 9 November 2014), Margaret Shearer in household of Daniel Shearer, Wayne county, Wayne, Kentucky, United States; citing family 334, NARA microfilm publication M432 (Washington, D.C.: National Archives and Records Administration, n.d.).
It may be possible to confirm family relationships with Margaret by comparing test results with other carriers of her mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share DNA with Margaret:
Vickery-840 and Vickery-426 appear to represent the same person because: There are two Margarets as daughters of Briles-20. Their birth and death dates appear different so perhaps one of them is from a different line?