Based on her parents' birth dates we can guess that Margaret was born around 1700.
The following is from Byberry Waltons (Norman Walton Swayne, 1958), pg 16:
13 MARGARET WALTON (3), daughter of 2 Nathaniel Walton & Martha Bownall of Byberry Twp, Phila. Co., Pa., was alive and wife of John Powell when her mother's will was drawn Feb. 10, 1736/7.
[(Reference : From the Book American Ancestry name and decent of the male line of Americans whose Ancestors Settled in the United States Previous to the Declaration of Independence A. D. 1776 Vol. Vll pg 56)] "we can see that a WALTON, MARTHA. Philadelphia. Widow- Daughter Margaret (wife of John Powell)
http://files.usgwarchives.org/pa/philadelphia/wills/willabstrbkf.txt - Sent using Google Toolbar
Notes:
This would probably be Margaret Walton and this John Powell died 1748, this evidence supports he is the Son of William first purchaser and this John in my opinion did not die young but after his marriage to Ann Harvard he may of left the area and started a new family (He may of been highly in dept) given his age compared to that of the would be second wife Margaret, his son Philip was not born till 1743, he died in 1748, it appears Margaret was much younger than he to have a child so late in his life. (KL)"
Pennsylvania, Wills and Probate Records, 1683-1993
Name: Margaret Powell
Probate Place: Lancaster, Pennsylvania, USA
Philadelphia, Pennsylvania, Death Certificates
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DNA Connections
It may be possible to confirm family relationships with Margaret by comparing test results with other carriers of her mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Margaret:
~0.78%Jan (Kauffman) Storey :
AncestryDNA, GEDmatch PH4393377[compare], yourDNAportal JANdd8c7ddf, Ancestry member roxigirl10
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Family Tree DNA Family Finder, GEDmatch PH4393377[compare], yourDNAportal JANdd8c7ddf, Ancestry member roxigirl10, FTDNA kit #B312638