"United States Census, 1850," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:M658-82F : accessed 19 March 2016), Jesse P Meek, Lawrence county, part of, Lawrence, Kentucky, United States; citing family 559, NARA microfilm publication M432 (Washington, D.C.: National Archives and Records Administration, n.d.).
I believe the 1850 Census shows William living with his aunt, Abigail (Weddington) Meek. (Based on the ages and relationship.)
"United States Census, 1870," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:MX4M-6R6 : 17 October 2014), William Weddington, Kentucky, United States; citing p. 8, family 50, NARA microfilm publication M593 (Washington D.C.: National Archives and Records Administration, n.d.); FHL microfilm 545,994.
Find a Grave, database and images (https://www.findagrave.com/memorial/48987573/william-h-weddington: accessed 16 December 2022), memorial page for William H Weddington (16 Dec 1826–20 Jul 1873), Find a Grave Memorial ID 48987573, citing Weddington Cemetery, Coal Run Village, Pike County, Kentucky, USA; Maintained by dawn williams (contributor 46637740).
Weddington Family Bible. American Bible Society, Stereotype Edition, 1829. Currently in possession of Eric Weddington. Includes names, birth, and death dates of family members from 1784.
The South Western Reporter, Volume 140, (West Publishing Company : 1912), "Polley v. Adkins, et al.", Court of Appeals of Kentucky, 15 November 1915, pp. 551-552,
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DNA Connections
It may be possible to confirm family relationships with William by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
Y-chromosome DNA test-takers in his direct paternal line on WikiTree:
11 Sep 1856 Pike, Kentucky, USA