George Willis married Katherine Matilda Adair (1878 - 1959)
there were no children
Sources
"Ireland Births and Baptisms, 1620-1881," database, FamilySearch (https://familysearch.org/ark:/61903/1:1:FGXV-FK9 : 10 February 2018), Sarah Jane Muldoon Willis in entry for Willis, 07 Nov 1879; citing Moneen, Fermanagh, Ireland, index based upon data collected by the Genealogical Society of Utah, Salt Lake City; FHL microfilm 256,044.
"Ireland Civil Registration, 1845-1913," database, FamilySearch (https://familysearch.org/ark:/61903/1:1:QP8D-43XZ : 24 September 2018), James Willis in entry for Willis, 7 Nov 1879; Birth; Enniskillen, County Fermanagh, Ireland; citing General Register Office, Southern Ireland; FHL microfilm .
"Ireland Civil Registration Indexes, 1845-1958," database, FamilySearch (https://familysearch.org/ark:/61903/1:1:FYXW-FJ3 : 10 March 2018), MARRIAGES entry for George Willis & Catherine M. Adair; citing Londonderry, Apr - Jun 1917, vol. 2, p. 133, General Registry, Custom House, Dublin; FHL microfilm 101,263.
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DNA Connections
It may be possible to confirm family relationships with George by comparing test results with other carriers of his ancestors' Y-chromosome or mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with George: